Regenerative endodontics is an emerging portion of endodontics that attempts to utilize the remarkable attributes of the human body to facilitate the regeneration of a tooth that has been compromised by disease and necrosis. The body of supporting research and evidence is rapidly evolving. It is opening new doors to treatment options and has the potential to introduce options to regenerate teeth that would otherwise be incompletely developed and compromised. These recommendations are based on best available data at this time and should be one possible source of information used by clinicians to make treatment decisions. Moreover, given the rapid evolving nature of this field, clinicians should actively review new findings as they become available.